Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, College Park, Maryland, USA.
Curr Opin Allergy Clin Immunol. 2012 Jun;12(3):323-30. doi: 10.1097/ACI.0b013e3283535aaf.
To review information in food allergy guidelines and the literature on assessing and understanding food allergic reaction risks.
Current food allergy guidelines have focused on tools for better diagnosis of food allergy and treatment of reactions. These guidelines have not addressed the growing body of literature on risk assessment and diagnostic tools being used to assess dose-response relationships in relation to food-allergen exposures. The literature includes substantial data from food-allergen challenges performed in sensitive individuals, and probabilistic modeling of these data may help to elucidate the relationship between allergen dose exposures, including thresholds, and reaction risk in allergic individuals. Understanding this relationship has potential to improve the health-related quality of life of allergic consumers.
Recent findings in the literature have highlighted improved diagnostic tools and other information that can be used to assess risks for allergic reaction to low-dose allergen exposures (thresholds) and reaction severity in food allergic consumers. Recommendations to better define and stratify allergic reaction risks for consumers could be adopted into guidelines for the diagnosis and clinical management of food allergy.
综述食物过敏指南和相关文献中的信息，评估和了解食物过敏反应风险。
目前的食物过敏指南侧重于更好地诊断食物过敏和治疗过敏反应的工具。这些指南没有涉及到越来越多的关于风险评估和诊断工具的文献，这些工具用于评估与食物过敏原暴露相关的剂量-反应关系。文献包括来自敏感个体进行的食物过敏原挑战的大量数据，对这些数据进行概率建模可能有助于阐明过敏原剂量暴露（包括阈值）与过敏个体反应风险之间的关系。了解这种关系有可能改善过敏消费者的健康相关生活质量。
文献中的最新发现强调了改进的诊断工具和其他信息，可用于评估食物过敏消费者对低剂量过敏原暴露（阈值）和过敏反应严重程度的过敏反应风险。更好地定义和分层过敏反应风险的建议可以被纳入食物过敏诊断和临床管理指南中。
