Department of Pediatrics, University of Minnesota, Minneapolis, MN 255455, USA.
Int J Obes (Lond). 2013 Mar;37(3):420-3. doi: 10.1038/ijo.2012.61. Epub 2012 Apr 17.
In obesity, adipose tissue becomes a significant source of chemokines and inflammatory cytokines that are associated with chronic systemic low-grade inflammation and may lead to insulin resistance. Studies in children have mainly focused on inflammatory cytokines and there are limited data for chemokines in adolescents and young adults. We studied the relation of chemokines to cardiovascular (CV)-risk factors, insulin resistance and adipocytokines in 18-21-year-old individuals.
Cross-sectional data collected in a cohort originally enrolled at mean age 13, with data for the present study obtained from 252 examined at age 18.7±0.1 years.
Multiple linear regression models were used to analyze the associations among chemokines (monocyte chemotactic protein-1, macrophage inflammatory protein-1β (MIP-1β), visfatin and interleukin-8 (IL-8)) and between chemokines and body mass index (BMI), glucose, lipids, blood pressure (BP), insulin resistance (euglycemic hyperinsulinemic clamp) and adipocytokines (IL-6, TNF-α and adiponectin).
Chemokine levels were significantly intercorrelated. Significant associations (P<0.05) with adjustment for age, race and sex included: MIP-1β with waist circumference and IL-6, IL-8 with systolic BP and visfatin with IL-6. No other significant relations were found between the chemokines and the other variables. Further adjustment for BMI did not alter these conclusions.
Considered in the context of prior studies in children and adults, these results suggest that in large part, the association between chemokines and CV risk or inflammatory factors does not appear to develop until adult life.
在肥胖症中，脂肪组织成为趋化因子和炎症细胞因子的重要来源，这些因子与慢性全身性低度炎症有关，并可能导致胰岛素抵抗。儿童研究主要集中在炎症细胞因子上，而青少年和年轻人的趋化因子数据有限。我们研究了 18-21 岁个体中趋化因子与心血管（CV）危险因素、胰岛素抵抗和脂肪细胞因子的关系。
本研究为横断面研究，数据来自于最初于平均年龄 13 岁时入组的队列，目前的研究数据来自于 252 名在 18.7±0.1 岁时接受检查的个体。
采用多元线性回归模型分析趋化因子（单核细胞趋化蛋白-1、巨噬细胞炎症蛋白-1β（MIP-1β）、内脏脂肪素和白细胞介素-8（IL-8））之间的相关性，以及趋化因子与体重指数（BMI）、血糖、血脂、血压（BP）、胰岛素抵抗（正葡萄糖高胰岛素钳夹）和脂肪细胞因子（IL-6、TNF-α和脂联素）之间的相关性。
趋化因子水平呈显著的相互关联。经年龄、种族和性别调整后，有统计学意义的关联（P<0.05）包括：MIP-1β与腰围和 IL-6，IL-8 与收缩压和内脏脂肪素与 IL-6。在这些趋化因子与其他变量之间没有发现其他显著关系。进一步调整 BMI 并没有改变这些结论。
根据先前在儿童和成人中的研究结果，这些结果表明，在很大程度上，趋化因子与 CV 风险或炎症因子之间的关联直到成年后才会出现。
