Loukeris Kristina, Vazquez Madeline F, Sica Gabriel, Wagner Patrick, Yankelevitz David F, Henschke Claudia I, Cham Matthew D, Saqi Anjali
Department of Pathology, Weill Cornell Medical Center, New York, NY, USA.
Diagn Cytopathol. 2012 May;40(5):380-7. doi: 10.1002/dc.21519. Epub 2010 Nov 22.
Fine needle aspirations biopsies, CT-guided and endobronchial ultrasound-guided, as a mode of diagnosing and/or staging lung carcinoma, are becoming more frequent. Also, there is greater necessity for classification of lung cancers into subcategories of squamous cell carcinoma and adenocarcinoma for appropriate management. Cytomorphology, based on smears alone, allows this classification in many instances. The aim of the current study was to explore the potential of cell blocks to increase the specificity of diagnosis. The morphological characteristics of sixty-two lung carcinomas were examined. Less well-differentiated squamous cell carcinomas were more readily classified as such on cell blocks. Likewise, cell block sections with architectural patterns including strips of cells, papillae and nests of cells correlated with bronchioalveolar, papillary and acinar/mixed subtypes of adenocarcinoma on follow-up histology. In conclusion, cell blocks provide additional morphological clues and material for ancillary studies for classification of lung carcinomas.
细针穿刺活检，包括CT引导和支气管内超声引导，作为诊断和/或分期肺癌的一种方式，正变得越来越频繁。此外，为了进行适当的治疗，将肺癌分类为鳞状细胞癌和腺癌亚类的必要性也越来越大。仅基于涂片的细胞形态学在许多情况下可以实现这种分类。本研究的目的是探讨细胞块提高诊断特异性的潜力。检查了62例肺癌的形态学特征。分化较差的鳞状细胞癌在细胞块上更容易被如此分类。同样，具有包括细胞条带、乳头和细胞巢等结构模式的细胞块切片与后续组织学上的细支气管肺泡癌、乳头状癌和腺泡/混合亚型腺癌相关。总之，细胞块为肺癌分类的辅助研究提供了额外的形态学线索和材料。
