淋巴结表达和检测在癌症中的应用：经验与挑战。
Nodal expression and detection in cancer: experience and challenges.
机构信息
Children's Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA.
出版信息
Cancer Res. 2012 Apr 15;72(8):1915-20. doi: 10.1158/0008-5472.CAN-11-3419.
Abstract
Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.
摘要
节是一种与 TGF-β 相关的胚胎形态发生素，在多种人类癌症中表达。如果不考虑与节转录和蛋白加工相关的问题，在这些组织中检测节的表达可能具有挑战性。在这里，我们讨论了与节表达和功能相关的某些特征，以及这些特征如何促进表达数据的获取和解释，有助于我们理解节在人类癌症中的潜在作用。我们还讨论了如何将节临床应用为癌症进展和治疗靶点的新型生物标志物。
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Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype.Notch4 通过调节胚胎形态发生素 Nodal 促进侵袭性黑色素瘤表型的表现。
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