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1
Nodal expression and detection in cancer: experience and challenges.淋巴结表达和检测在癌症中的应用：经验与挑战。
Cancer Res. 2012 Apr 15;72(8):1915-20. doi: 10.1158/0008-5472.CAN-11-3419.
2
Embryonic morphogen nodal promotes breast cancer growth and progression.胚胎形态发生素 nodal 促进乳腺癌的生长和进展。
PLoS One. 2012;7(11):e48237. doi: 10.1371/journal.pone.0048237. Epub 2012 Nov 7.
3
Nodal morphogens.节状形态发生素。
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a003459. doi: 10.1101/cshperspect.a003459.
4
Back to the embryonic stage: Nodal as a biomarker for breast cancer progression.回到胚胎期：Nodal 作为乳腺癌进展的生物标志物。
Breast Cancer Res. 2012 May 21;14(3):105. doi: 10.1186/bcr3177.
5
Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer.胚胎形态发生素 Nodal 在乳腺癌中的预后和预测生物标志物潜力。
Breast Cancer Res. 2012 May 11;14(3):R75. doi: 10.1186/bcr3185.
6
Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression.Nodal和Cripto-1的新作用：从胚胎发生到乳腺癌进展
Breast Dis. 2008;29:91-103. doi: 10.3233/bd-2008-29110.
7
Embryonic protein nodal promotes breast cancer vascularization.胚胎蛋白 nodal 促进乳腺癌血管生成。
Cancer Res. 2012 Aug 1;72(15):3851-63. doi: 10.1158/0008-5472.CAN-11-3951.
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Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers.靶向 Nodal 和 Cripto-1：双重潜在治疗癌症生物标志物的新视角。
Curr Med Chem. 2019;26(11):1994-2050. doi: 10.2174/0929867325666180912104707.
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Expression of nodal signalling components in cycling human endometrium and in endometrial cancer.周期性人子宫内膜和子宫内膜癌中淋巴结信号成分的表达。
Reprod Biol Endocrinol. 2009 Oct 29;7:122. doi: 10.1186/1477-7827-7-122.
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Embryonic morphogen nodal is associated with progression and poor prognosis of hepatocellular carcinoma.胚胎形态发生素节点蛋白与肝细胞癌的进展及不良预后相关。
PLoS One. 2014 Jan 21;9(1):e85840. doi: 10.1371/journal.pone.0085840. eCollection 2014.

引用本文的文献

1
Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy.高的淋巴结表达通常与黑色素瘤患者的预后较差相关，且这些患者接受了抗 PD-1 治疗。
Pathol Oncol Res. 2024 Sep 23;30:1611889. doi: 10.3389/pore.2024.1611889. eCollection 2024.
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, a Natural Antisense Transcript of , Promotes Tumour Progression and Metastasis in Melanoma.，一种的天然反义转录本，促进黑色素瘤的肿瘤进展和转移。 （你提供的原文内容似乎不完整，存在信息缺失的情况，以上是按照现有内容翻译的。）
Noncoding RNA. 2023 Nov 15;9(6):71. doi: 10.3390/ncrna9060071.
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Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with Wilms tumour.免疫相关基因特征与免疫图谱相关，并能准确预测肾母细胞瘤患者的预后。
Front Immunol. 2022 Sep 12;13:920666. doi: 10.3389/fimmu.2022.920666. eCollection 2022.
4
Hypoxia induced-disruption of lncRNA TUG1/PRC2 interaction impairs human trophoblast invasion through epigenetically activating Nodal/ALK7 signalling.低氧诱导长链非编码 RNA TUG1/PRC2 相互作用破坏，通过表观遗传激活 Nodal/ALK7 信号通路损害人滋养细胞侵袭。
J Cell Mol Med. 2022 Jul;26(14):4087-4100. doi: 10.1111/jcmm.17450. Epub 2022 Jun 21.
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Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity.正常皮肤细胞通过促进上皮间质转化增加皮肤黑色素瘤的侵袭性，其途径为激活 nodal 和 Wnt 信号通路。
Int J Mol Sci. 2021 Oct 29;22(21):11719. doi: 10.3390/ijms222111719.
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Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy.Cripto-1作为癌症干细胞免疫治疗的潜在靶点
Cancers (Basel). 2021 May 20;13(10):2491. doi: 10.3390/cancers13102491.
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Biological effects of NODAL on endometrial cancer cells and its underlying mechanisms.NODAL对子宫内膜癌细胞的生物学效应及其潜在机制。
Exp Ther Med. 2021 Apr;21(4):402. doi: 10.3892/etm.2021.9833. Epub 2021 Feb 25.
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TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment.TGFB1/INHBA 同源二聚体/Nodal-SMAD2/3 信号通路：PDAC 治疗的关键分子靶点。
Mol Ther. 2021 Mar 3;29(3):920-936. doi: 10.1016/j.ymthe.2021.01.002. Epub 2021 Jan 9.
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A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles.通过对CRIPTO生物学作用的文献计量分析对科学文献中CRIPTO的作用进行多学科综述。
Cancers (Basel). 2020 Jun 5;12(6):1480. doi: 10.3390/cancers12061480.
10
Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.淋巴结可诱导卵巢子宫内膜异位症透明细胞癌病变细胞凋亡并抑制增殖。
BMC Cancer. 2019 Apr 3;19(1):308. doi: 10.1186/s12885-019-5539-y.

本文引用的文献

1
Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells.胚胎节点信号的再激活与肿瘤进展相关，并促进前列腺癌细胞的生长。
Prostate. 2011 Aug 1;71(11):1198-209. doi: 10.1002/pros.21335. Epub 2011 Jan 12.
2
Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype.Notch4 通过调节胚胎形态发生素 Nodal 促进侵袭性黑色素瘤表型的表现。
Cancer Res. 2010 Dec 15;70(24):10340-50. doi: 10.1158/0008-5472.CAN-10-0705.
3
Targeting BRAF for patients with melanoma.针对黑色素瘤患者的 BRAF 靶向治疗。
Br J Cancer. 2011 Feb 1;104(3):392-8. doi: 10.1038/sj.bjc.6606030. Epub 2010 Dec 7.
4
Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS).原发性与复发性乳腺癌生物标志物状态变化的前瞻性比较：组织中乳腺癌复发研究（BRITS）。
Breast Cancer Res. 2010;12(6):R92. doi: 10.1186/bcr2771. Epub 2010 Nov 8.
5
Targeting breast cancer stem cells.针对乳腺癌干细胞。
J Clin Oncol. 2010 Sep 1;28(25):4006-12. doi: 10.1200/JCO.2009.27.5388. Epub 2010 May 24.
6
Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment.用胚胎微环境重编程转移性肿瘤细胞。
Epigenomics. 2009 Dec;1(2):387-98. doi: 10.2217/epi.09.25.
7
Expression of the embryonic morphogen Nodal in cutaneous melanocytic lesions.胚胎形态发生素 Nodal 在皮肤黑色素细胞病变中的表达。
Mod Pathol. 2010 Sep;23(9):1209-14. doi: 10.1038/modpathol.2010.101. Epub 2010 May 21.
8
The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts.胚胎形态发生素Nodal与人类恶性黑色素瘤异种移植瘤中的通道样结构相关。
J Cutan Pathol. 2010 Apr;37 Suppl 1(Suppl 1):19-25. doi: 10.1111/j.1600-0560.2010.01503.x.
9
Nodal promotes growth and invasion in human gliomas.节结蛋白促进人脑胶质瘤的生长和侵袭。
Oncogene. 2010 May 27;29(21):3110-23. doi: 10.1038/onc.2010.55. Epub 2010 Apr 12.
10
Nodal morphogens.节状形态发生素。
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a003459. doi: 10.1101/cshperspect.a003459.

淋巴结表达和检测在癌症中的应用：经验与挑战。

Nodal expression and detection in cancer: experience and challenges.

机构信息

Children's Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA.

出版信息

Cancer Res. 2012 Apr 15;72(8):1915-20. doi: 10.1158/0008-5472.CAN-11-3419.

DOI:10.1158/0008-5472.CAN-11-3419
PMID:22508696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3334352/
Abstract

Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

摘要

节是一种与 TGF-β 相关的胚胎形态发生素，在多种人类癌症中表达。如果不考虑与节转录和蛋白加工相关的问题，在这些组织中检测节的表达可能具有挑战性。在这里，我们讨论了与节表达和功能相关的某些特征，以及这些特征如何促进表达数据的获取和解释，有助于我们理解节在人类癌症中的潜在作用。我们还讨论了如何将节临床应用为癌症进展和治疗靶点的新型生物标志物。