开发 S 期调控。
Developing S-phase control.
机构信息
Department of Biology, Department of Genetics, Lineberger Comprehensive Cancer Center, Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Genes Dev. 2012 Apr 15;26(8):746-50. doi: 10.1101/gad.191171.112.
Abstract
The duration of S phase in early embryos is often short, and then increases as development proceeds because of the appearance of late-replicating regions of the genome. In the April 1, 2012, issue of Genes & Development, Farrell and colleagues (pp. 714-725) demonstrate that the down-regulation of cyclin-dependent kinase 1 (Cdk1) activity triggers the onset of late-replicating DNA and an increase in S-phase length in Drosophila embryos, revealing an unexpected role for Cdk1 in replication control during development.
摘要
早期胚胎中 S 期的持续时间通常较短，随着发育的进行，由于基因组中晚期复制区域的出现而增加。在 2012 年 4 月 1 日的《基因与发育》杂志上，Farrell 及其同事（第 714-725 页）表明，细胞周期蛋白依赖性激酶 1（Cdk1）活性的下调触发了晚期复制 DNA 的开始和 S 期长度的增加，揭示了 Cdk1 在发育过程中复制控制中的一个意外作用。
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本文引用的文献
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