Department of Biology, Department of Genetics, Lineberger Comprehensive Cancer Center, Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA.
Genes Dev. 2012 Apr 15;26(8):746-50. doi: 10.1101/gad.191171.112.
The duration of S phase in early embryos is often short, and then increases as development proceeds because of the appearance of late-replicating regions of the genome. In the April 1, 2012, issue of Genes & Development, Farrell and colleagues (pp. 714-725) demonstrate that the down-regulation of cyclin-dependent kinase 1 (Cdk1) activity triggers the onset of late-replicating DNA and an increase in S-phase length in Drosophila embryos, revealing an unexpected role for Cdk1 in replication control during development.
早期胚胎中 S 期的持续时间通常较短，随着发育的进行，由于基因组中晚期复制区域的出现而增加。在 2012 年 4 月 1 日的《基因与发育》杂志上，Farrell 及其同事（第 714-725 页）表明，细胞周期蛋白依赖性激酶 1（Cdk1）活性的下调触发了晚期复制 DNA 的开始和 S 期长度的增加，揭示了 Cdk1 在发育过程中复制控制中的一个意外作用。
