Tsacopoulos M, Pournaras C J
Laboratoire d'Ophtalmologie expérimentale, Hôpital cantonal universitaire, Genève.
Ophtalmologie. 1990 Jan-Feb;4(1):20-1.
Hypercapnia causes vasodilatation of retinal arterioles. Prostaglandin E1, injected close to retinal arterioles from the vitreal side cause vasodilatation apparently similar to that caused by hypercapnia. An inhibitor of prostaglandin synthase (indomethacin) was injected into the ocular circulation. There was a reversible inhibition of the retinal vasodilatation normally induced by hypercapnia. Indomethacin injected close to retinal arterioles from the vitreal side causes reversible vasoconstriction and inhibits the vasodilatory effect of hypercapnia. It is concluded that prostaglandin E1 satisfies three criteria for a candidate for a mediator of hypercapnia-induced arteriolar dilatation.
高碳酸血症会导致视网膜小动脉血管扩张。从玻璃体一侧靠近视网膜小动脉注射前列腺素E1，会引起明显类似于高碳酸血症所导致的血管扩张。将一种前列腺素合成酶抑制剂（吲哚美辛）注入眼循环。高碳酸血症通常所诱导的视网膜血管扩张出现了可逆性抑制。从玻璃体一侧靠近视网膜小动脉注射吲哚美辛会导致可逆性血管收缩，并抑制高碳酸血症的血管舒张作用。得出的结论是，前列腺素E1符合作为高碳酸血症诱导小动脉扩张介质候选物的三个标准。
