State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Chem Soc Rev. 2012 Jun 7;41(11):4126-39. doi: 10.1039/c2cs35007f. Epub 2012 Apr 16.
Transition metal-catalyzed enantioselective hydrogenation of enamines is undoubtedly a useful and environment-friendly method for the preparation of optically pure chiral amines and amine derivatives. Over the last few decades, the use of transition metal catalysts containing chiral phosphorus or phosphine-oxazoline ligands attracted much attention for the hydrogenation of unprotected enamines. A number of efficient chiral catalysts have been developed, and some of them have shown high potential for the application in the synthesis of optical chiral amines in both laboratory and industry. This tutorial review focuses on the contributions concerning the transition metal-catalyzed enantioselective hydrogenation of unprotected enamines for the synthesis of chiral amines and amine derivatives.
过渡金属催化的烯胺的对映选择性氢化无疑是一种有用且环保的方法，可用于制备光学纯手性胺和胺衍生物。在过去的几十年中，使用含有手性磷或膦-恶唑啉配体的过渡金属催化剂引起了人们对未保护的烯胺氢化的极大关注。已经开发了许多有效的手性催化剂，其中一些在实验室和工业中合成光学手性胺方面显示出很高的应用潜力。本综述重点介绍了有关过渡金属催化的未保护烯胺对映选择性氢化用于合成手性胺和胺衍生物的贡献。
