Luo Jin-Hong, Zheng Bing-Hui, Fu Qing, Hung Min-Sheng
School of Resource and Environmental Sciences, East China Normal University, Shanghai 200062, China.
Huan Jing Ke Xue. 2012 Feb;33(2):342-5.
It was an urgent problem to determine short-term exposure safety concentration of genetic carcinogens in water pollution accident in China. Based on the hypothesis that the relationship between exposure dosage and carcinogenic risk was linear, the calculation process of genetic carcinogens safety concentration was put forwarded, and the method using life-time exposed safety concentration to calculate short-term exposure safety concentration was set up. Based on the statistical result of water pollution accident occurred in china during 2000-2010, arsenic was a major characteristic contaminate in water pollution accident. According to the method of short-term exposure safety concentration of genotoxic carcinogens, the safety concentration of arsenic was 0.5 mg x L(-1), it showed that the method was feasible in emergence management of water pollution accident.
确定我国水污染事故中遗传致癌物的短期暴露安全浓度是一个紧迫的问题。基于暴露剂量与致癌风险之间呈线性关系的假设,提出了遗传致癌物安全浓度的计算过程,并建立了用终身暴露安全浓度计算短期暴露安全浓度的方法。根据2000 - 2010年我国发生的水污染事故统计结果,砷是水污染事故中的主要特征污染物。按照遗传毒性致癌物短期暴露安全浓度的方法,砷的安全浓度为0.5 mg·L⁻¹,表明该方法在水污染事故应急管理中是可行的。