Py-Im 聚酰胺的药代动力学取决于其结构：环状与线性。
Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.
机构信息
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
出版信息
J Am Chem Soc. 2012 May 9;134(18):7995-9. doi: 10.1021/ja302588v. Epub 2012 Apr 24.
Abstract
The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provide a foundation for design of DNA binding Py-Im polyamides to be tested in vivo.
摘要
研究了三种吡咯-咪唑（Py-Im）多聚体的药代动力学特性，它们的大小和 Py-Im 含量相似，但形状不同。值得注意的是，设计用于相同 DNA 序列 5'-WGGWWW-3'的发夹和环状寡聚物表现出不同的药代动力学特性。此外，发夹 1 和环 2 表现出截然不同的动物毒性。这些数据为设计用于体内测试的 DNA 结合 Py-Im 多聚体提供了基础。
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