School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Food Chem Toxicol. 2012 Jun;50(6):1902-10. doi: 10.1016/j.fct.2012.04.001. Epub 2012 Apr 9.
Lysine-rich rice (LR) is a transgenic rice produced by fusion protein expressed genes into the germline of rice seeds. Compositional analysis of LR showed that the absolute concentration of lysine was significantly higher as compared to a near-isogenic non-transgenic rice. Lysine is believed to be the first limiting essential amino acid in rice, it is important to improve lysine content on rice nutritional quality. Here we report the results of a three generation study comparing the outcome in rats fed the transgenic rice to those fed conventional, near-isogenic rice or a control diet. In the study, both clinical performance variables and pathological responses such as body weight, food consumption, reproductive data, hematological parameters, serum chemistry and relative organ weights were examined respectively. It was evident that there were no adverse effects observed in rats that were fed transgenic rice compared with non-transgenic rice. There were significant differences in some hematology, serum chemistry parameters and relative organ weights in rats consuming the transgenic rice diet or non-transgenic rice diet compared with the control diet, but no macroscopic or histological adverse effects were observed. So the results from this study demonstrate that LR rice is as safe as near-isogenic non-transgenic rice.
赖氨酸丰富的水稻（LR）是一种通过融合蛋白将表达基因转入水稻种子的生殖细胞而产生的转基因水稻。LR 的成分分析表明，与近等基因非转基因水稻相比，赖氨酸的绝对浓度明显更高。赖氨酸被认为是水稻中第一限制必需氨基酸，提高赖氨酸含量对于提高水稻的营养价值非常重要。在这里，我们报告了一项三代研究的结果，该研究比较了喂食转基因水稻的大鼠与喂食常规近等基因水稻或对照饮食的大鼠的结果。在这项研究中，分别检查了临床性能变量和病理反应，如体重、食物消耗、生殖数据、血液学参数、血清化学和相对器官重量。显然，与非转基因水稻相比，喂食转基因水稻的大鼠没有观察到不良反应。与对照组相比，食用转基因水稻或非转基因水稻的大鼠的一些血液学、血清化学参数和相对器官重量存在显著差异，但未观察到宏观或组织学不良反应。因此，这项研究的结果表明，LR 水稻与近等基因非转基因水稻一样安全。
