富含β-胡萝卜素的转基因大米亚慢性经口毒性研究。
Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats.
机构信息
Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
出版信息
Int J Environ Res Public Health. 2021 May 21;18(11):5526. doi: 10.3390/ijerph18115526.
(1) Background: a hybrid black rice rich in β-carotene carrying the and genes (HJM) was evaluated in Wistar rats by a 90-day feeding study, aiming to assess its dietary safety. (2) Methods: the HJM rice and its parental line HS were included in rats' diets at levels of 73.5% and 75.5%, respectively. The AIN-93 diet was administered as a nutritional control. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. (3) Results: Some parameters were found to be significantly different, though they remained within the normal range for rats of this breed and age. In addition, upon sacrifice, various organs were weighed, and macroscopic and histopathological examinations were performed, with only minor changes to report. (4) Conclusions: HJM rice exhibited no adverse or toxic effects in Wistar rats in this 90-day study.
（1）背景：一种富含β-胡萝卜素的杂交黑米，携带 和 基因（HJM），通过 90 天喂养研究在 Wistar 大鼠中进行了评估，旨在评估其饮食安全性。（2）方法：HJM 大米及其亲本 HS 分别以 73.5%和 75.5%的水平添加到大鼠饮食中。AIN-93 饮食作为营养对照。在研究期间，未观察到动物行为或体重增加出现不良反应。采集血液样本并进行分析，比较标准血液学和生化学参数。（3）结果：发现一些参数存在显著差异，但仍在该品种和年龄大鼠的正常范围内。此外，在处死时，对各种器官进行称重，并进行宏观和组织病理学检查，仅报告一些微小的变化。（4）结论：在这项 90 天的研究中，HJM 大米在 Wistar 大鼠中未表现出不良或有毒作用。
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