Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
EMBO J. 2012 May 16;31(10):2240-1. doi: 10.1038/emboj.2012.116. Epub 2012 Apr 17.
EMBO J 31 10, 2275–2295 (2012); published online April 17 2012 The Foxo1 forkhead transcription factor is a critical negative regulator of insulin action. In this issue of , Nakae and colleagues (Nakae et al, 2012) describe a novel Foxo1 Co-Repressor (FCoR) protein in adipocytes, showing that FCoR enhances the acetylation of Foxo1 to inhibit Foxo1 activity, promote adipocyte differentiation, and improve insulin sensitivity.
EMBO J 31 10, 2275–2295 (2012); published online April 17 2012 叉头框转录因子 O1 是胰岛素作用的关键负调控因子。在本期的 ，中，中井和他的同事（Nakae 等人，2012）描述了脂肪细胞中的一种新的 Foxo1 共阻遏物（FCoR）蛋白，表明 FCoR 增强 Foxo1 的乙酰化，以抑制 Foxo1 活性，促进脂肪细胞分化，并提高胰岛素敏感性。
