Department of Neurology, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
J Neurosci Res. 2012 Sep;90(9):1681-92. doi: 10.1002/jnr.23062. Epub 2012 Apr 19.
No clear consensus has been reached on the Interleukin-1A (IL-1A) -889C/T polymorphism and Alzheimer's disease (AD) risk. In this meta-analysis, 27 case-control studies were assessed to evaluate the possible association. Overall, positive associations of the IL-1A -889C/T polymorphism with AD risk were found in allele comparison T vs. C (OR = 1.09, 95% CI = 1.01-1.18), recessive model TT vs. CT + CC (OR = 1.21, 95% CI = 1.01-1.45), and homozygote comparison (TT vs. CC; OR = 1.32, 95% CI = 1.04-1.67). In subgroup analysis stratified by ethnicity, significant associations were demonstrated in Caucasians but not in Asians. In subgroup analysis according to the age of onset, the data showed a significant association in patients with late-onset AD in Caucasians but not in early-onset AD. In conclusion, this meta-analysis supports the idea that IL-1A -889C/T polymorphism is capable of causing AD and LOAD susceptibility in Caucasians but not in Asians.
白细胞介素-1A（IL-1A）-889C/T 多态性与阿尔茨海默病（AD）风险之间尚未达成明确共识。在这项荟萃分析中，评估了 27 项病例对照研究，以评估可能的关联。总体而言，在等位基因比较 T 与 C（OR = 1.09，95％CI = 1.01-1.18）、隐性模型 TT 与 CT + CC（OR = 1.21，95％CI = 1.01-1.45）和纯合子比较（TT 与 CC；OR = 1.32，95％CI = 1.04-1.67）中，IL-1A-889C/T 多态性与 AD 风险呈正相关。按种族分层的亚组分析显示，白种人中存在显著相关性，但在亚洲人中不存在。根据发病年龄的亚组分析，白种人中晚发性 AD 患者的数据显示出显著相关性，但在早发性 AD 中没有。总之，这项荟萃分析支持这样的观点，即 IL-1A-889C/T 多态性能够导致白种人中的 AD 和 LOAD 易感性，但不能导致亚洲人中的 AD 和 LOAD 易感性。
