Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista-UNESP Rodovia Araraquara-Jaú Km1, 14801-902, Araraquara, SP, Brazil.
J Biomed Nanotechnol. 2012 Apr;8(2):280-9. doi: 10.1166/jbn.2012.1373.
In the last few decades, nanotechnology has led to an advance in the development of topical drug delivery. Nanostructured drug delivery systems enable the compartmentalization of drugs in restricted environments, modifying the release profile and maintaining the required drug concentration for prolonged periods at the site of action and/or absorption. The development of nanostructured systems containing surfactants has evolved rapidly. Mixtures of surfactant, oil and water can self-associate to form structures, such as microemulsions and liquid crystal phases, which can be exploited as drug delivery systems because their nanostructured organization can control drug release. Therefore, the purpose of this study was to assess the potential of systems containing polyoxypropylene (5) polyoxyethylene (20) cetyl ether as surfactant, oleic acid or mineral oil as the oily phase, and water to be used as a platform in the development of topical drug delivery systems. Physicochemical characterization of the systems was performed by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological tests and texture profile analysis. The ternary phase diagrams showed that combinations of surfactant/mineral oil/water and surfactant/oleic acid/water could form various thermodynamically stable structures, such as microemulsions and liquid crystals. The oily phases, oleic acid and mineral oil, changed the rheological, mechanical and adhesive properties of systems containing polyoxypropylene (5) polyoxyethylene (20) cetyl ether.
在过去的几十年中，纳米技术推动了局部药物传递系统的发展。纳米结构药物传递系统能够将药物局限在特定环境中，改变药物的释放特性，并在作用部位和/或吸收部位维持所需的药物浓度。含有表面活性剂的纳米结构系统的开发迅速发展。表面活性剂、油和水的混合物可以自组装形成结构，如微乳液和液晶相，这些结构可以被用作药物传递系统，因为它们的纳米结构组织可以控制药物的释放。因此，本研究的目的是评估含有聚氧丙烯（5）聚氧乙烯（20）十六醚作为表面活性剂、油酸或矿物油作为油相、水作为平台的系统在局部药物传递系统开发中的潜力。通过偏光显微镜（PLM）、小角 X 射线散射（SAXS）、流变学测试和质地分析对系统进行了物理化学特性分析。三元相图表明，表面活性剂/矿物油/水和表面活性剂/油酸/水的组合可以形成各种热力学稳定的结构，如微乳液和液晶。油性相油酸和矿物油改变了含有聚氧丙烯（5）聚氧乙烯（20）十六醚的系统的流变学、力学和粘附特性。
