Kondo Yasuteru, Ueno Yoshiyuki, Shimosegawa Tooru
Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba-ku, Sendai City, Miyagi 980-8574, Japan.
Int J Microbiol. 2012;2012:647581. doi: 10.1155/2012/647581. Epub 2012 Feb 22.
It has been reported that HCV can infect not only hepatocytes but also various kinds of lymphoid cells. Although many reports have described the biological significance of lymphotropic HCV, the issue remains controversial since the target lymphoid cells might have various kinds of functions in the immune system. One of the important roles of lymphoid cells in HCV replication is being a reservoir of HCV. Several groups described the detection of HCV-RNA in lymphoid cells after HCV eradication in plasma. Another important role of lymphotropic HCV is that it acts as a carcinogenic agent and induces immune dysfunction. In this paper, we summarize the reports regarding the biological significance of lymphotropic HCV in representative lymphoid cells.
据报道，丙型肝炎病毒（HCV）不仅可以感染肝细胞，还能感染各种淋巴细胞。尽管许多报告描述了嗜淋巴细胞性HCV的生物学意义，但由于靶淋巴细胞在免疫系统中可能具有多种功能，该问题仍存在争议。淋巴细胞在HCV复制中的一个重要作用是作为HCV的储存库。几个研究小组描述了在血浆中HCV清除后在淋巴细胞中检测到HCV-RNA。嗜淋巴细胞性HCV的另一个重要作用是它作为一种致癌剂并诱导免疫功能障碍。在本文中，我们总结了关于嗜淋巴细胞性HCV在代表性淋巴细胞中的生物学意义的报告。
