慢性丙型肝炎患者外周血记忆 B 细胞对细胞凋亡有抗性。
Peripheral blood memory B cells are resistant to apoptosis in chronic hepatitis C patients.
机构信息
Department of Research on Blood and Biological Products, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
出版信息
Virus Res. 2011 Jan;155(1):349-51. doi: 10.1016/j.virusres.2010.09.017. Epub 2010 Sep 25.
Our recent study indicated that peripheral B cells in chronic hepatitis C (CHC) patients were infected with hepatitis C virus (HCV). It was also demonstrated that the frequency of CD27(+) B cells, i.e. memory phenotype, was significantly reduced in the peripheral blood of CHC patients. An assumption was made by these findings that the CD27(+) B cells are susceptible to apoptosis when infected with HCV. Therefore, in this study, the susceptibility of CD27(+) B cells to apoptosis in CHC patients was analyzed. Contrary to our assumption, it was found that CD27(+) B cells are more resistant to apoptosis than the counterpart subset, i.e. CD27(-) B cells. The rationale for this finding is discussed with regard to the possible role for memory B cells as an HCV reservoir for persistent infection in CHC patients.
我们最近的研究表明，慢性丙型肝炎（CHC）患者的外周 B 细胞感染了丙型肝炎病毒（HCV）。研究还表明，CHC 患者外周血中 CD27(+) B 细胞的频率，即记忆表型，显著降低。这些发现表明，当感染 HCV 时，CD27(+) B 细胞容易发生细胞凋亡。因此，在这项研究中，分析了 CHC 患者 CD27(+) B 细胞对细胞凋亡的敏感性。与我们的假设相反，研究发现 CD27(+) B 细胞比对照亚群（即 CD27(-) B 细胞）更不易发生细胞凋亡。本文就记忆 B 细胞作为 CHC 患者持续性感染 HCV 的潜在病毒储存库的可能作用，对这一发现的原理进行了讨论。
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