Abendroth K
Klinik für Innere Medizin, Friedrich-Schiller-Universität, Jena, BRD.
Wien Med Wochenschr. 1990 Oct 15;140(18-19):482-4.
Fluorine has an effect on the bone, it increases both the number and the activity of osteoblasts and, thus, at first leads to an osteoidosis. The mineralization is somewhat lagging behind. This mode of action is best suited for low-turnover osteoporosis. For all other forms of osteoporosis, such as high-turnover osteoporosis, osteoporomalacia and mixed osteopathies, fluorine therapy as the sole treatment is not optimal. In our opinion, it is not the action principle "fluorine" that is insufficient or dangerous, but the indication for this therapy was not given in case of treatment failures or certain side effects. The decisive progress in the treatment of osteoporosis is to be expected from an essentially improved and pathophysiologically oriented differential diagnosis and the resulting differential therapy.
氟对骨骼有影响，它会增加成骨细胞的数量和活性，因此起初会导致骨样骨病。矿化过程会稍有滞后。这种作用方式最适合低转换型骨质疏松症。对于所有其他形式的骨质疏松症，如高转换型骨质疏松症、骨质软化症和混合性骨病，单纯使用氟治疗并非最佳选择。我们认为，并非“氟”这种作用原理不足或危险，而是在治疗失败或出现某些副作用的情况下，未给出这种疗法的适应证。骨质疏松症治疗的决定性进展有望来自本质上得到改善且以病理生理学为导向的鉴别诊断以及由此产生的个体化治疗。
