Duursma S A, Raymakers J A
Academisch Ziekenhuis, afd. Geriatrie, Utrecht.
Ned Tijdschr Geneeskd. 1998 Aug 22;142(34):1915-9.
Fluoride changes the composition of the hydroxyapatite crystal, reducing the solubility of the bone crystals. Fluoride also stimulates the production of DNA and new osteoblasts, which results in formation of new bone. The therapeutical range of fluoride is narrow. With monofluorophosphate in a dose of 76 mg twice daily positive effect on bone mass is obtained and measurement of serum fluoride concentration is unnecessary. For the treatment of osteoporosis the best result could be obtained with a combined treatment with monofluorophosphate, stimulating osteoblasts and production of new bone, and a bisphosphonate, which simultaneously inhibits osteoclasts and bone resorption. Using this combined treatment only few side effects and no lower extremity pain syndrome were observed. Patients > 65 years of age and younger patients showed similar positive effects on bone mass.
氟化物会改变羟基磷灰石晶体的成分，降低骨晶体的溶解度。氟化物还会刺激DNA和新的成骨细胞的产生，从而导致新骨形成。氟化物的治疗范围较窄。每日两次服用76毫克单氟磷酸可对骨量产生积极影响，且无需测量血清氟浓度。对于骨质疏松症的治疗，将刺激成骨细胞和新骨生成的单氟磷酸与同时抑制破骨细胞和骨吸收的双膦酸盐联合使用，可取得最佳效果。采用这种联合治疗方法，仅观察到很少的副作用，且未出现下肢疼痛综合征。65岁以上的患者和年轻患者对骨量均显示出类似的积极影响。
