Research Department of Infection & Population Health, University College London, London, UK.
BMC Public Health. 2012 Jun 25;12:296. doi: 10.1186/1471-2458-12-296.
It is known that being on antiretroviral therapy reduces the risk of HIV transmission through sex. However it remains unknown what the absolute level of risk of transmission is in a person on ART with most recent measured HIV plasma viral load<50 c/mL in the absence of condom use. There are no data on risk of transmission for anal sex in MSM when the index partner is on ART.
METHODS/DESIGN: The PARTNER study is an international, observational multi-centre study, taking place from 2010 to 2014 in which HIV serodifferent partnerships who at enrolment reported recently having had condom-less vaginal or anal sexual intercourse are followed over time, with 46 monthly reporting of transmission risk behaviour through a confidential self completed risk behaviour questionnaire and with 46 monthly HIV testing for the HIV negative partner. The objective is to study (i) the risk of HIV transmission to partners, in particular in partnerships that continue not to use condoms consistently and the HIV-positive partner is on therapy with a viral load<50 copies/mL and (ii) why some partnerships do not use condoms, to describe the proportion who begin to adopt consistent condom use, and factors associated with this. For any negative partner who becomes infected phylogenetic analysis will be used following anonymisation of the samples to assess if transmission had been from the HIV infected partner.
This observational study will provide missing information on the absolute risk of HIV transmission for both vaginal and anal sex when the index case is on ART with a VL<50 copies/mL in the absence of condom use.
众所周知，抗逆转录病毒疗法（ART）可降低通过性行为传播 HIV 的风险。然而，在没有使用安全套的情况下，对于最近测量的 HIV 血浆病毒载量<50 拷贝/毫升且正在接受 ART 的个体，其传播风险的绝对水平仍不清楚。目前尚无关于接受 ART 的男性同性性行为（MSM）中肛交传播风险的数据。
方法/设计：PARTNER 研究是一项国际性、观察性多中心研究，于 2010 年至 2014 年进行，研究对象为在入组时报告最近发生过无保护阴道或肛交性行为的 HIV 血清学不同的性伴侣，随访时间为 46 个月，通过保密的自我完成的风险行为问卷报告 46 次传播风险行为，并对 HIV 阴性伴侣进行 46 次 HIV 检测。其目的是研究（i）HIV 传播给性伴侣的风险，特别是在持续不使用安全套且 HIV 阳性伴侣正在接受治疗且病毒载量<50 拷贝/毫升的情况下，以及（ii）为什么有些伴侣不使用安全套，描述开始持续使用安全套的比例以及与这种行为相关的因素。对于任何感染的阴性伴侣，将对样本进行匿名化处理，以进行系统进化分析，以评估传播是否来自 HIV 感染的伴侣。
这项观察性研究将提供在没有使用安全套的情况下，对于接受 ART 的个体，当病毒载量<50 拷贝/毫升时，HIV 通过阴道和肛门性交传播的绝对风险的缺失信息。
