Grudev D
Akush Ginekol (Sofiia). 1990;29(3):14-8.
In 51 chronological prolonged pregnancies at 42 weeks gestation the preparation and induction was made usage of the Soviet spasmolytic preparation Aprophen. Aprophen blocks also N-cholinergic receptors in sympathetic ganglia. The tocolytic action of sympathetic system on uterine musculature was removed as well as its tonic alpha-adrenergic effect on the cervix. Thirty pregnant women were included in a control comparative group, in whom induction and preparation of labour activity was achieved by usage of corticosteroids-Prednisolone. The medication in both groups continued till beginning of labour activity, but in failure after 96 h till oxytocin indication. In 77% of women, treated with Aprophen, labour activity occurred before 96 h (40 out of 51 women but 50% of women treated with Predinisolone (15 out of 30 women)/p less than 0.02/. In 31% of women, treated with Aprophen, labour activity was induced by oxytocin stimulation (14 out of 40 women, but in 76% of women, treated with Predinisolone (10 out of 15 women)/p less than 0.05/. The high percentage of children delivered with signs of postmaturity according to Clifford in pregnant women treated with corticosteroid--23.3% against 9.8% of women treated with Aprophen (p less than 0.01) show the connection between the usage of corticosteroids and the increase of the frequency of signs of postmaturity in newborns.
在51例妊娠42周的延期妊娠病例中，使用苏联解痉制剂阿普罗芬进行引产准备。阿普罗芬还能阻断交感神经节中的N - 胆碱能受体。这样就消除了交感神经系统对子宫肌层的宫缩抑制作用及其对宫颈的强直性α - 肾上腺素能效应。30名孕妇被纳入对照比较组，在该组中通过使用皮质类固醇泼尼松龙来实现引产准备。两组的用药都持续到分娩活动开始，但如果96小时后仍未成功则改用缩宫素。在使用阿普罗芬治疗的女性中，77%（51名女性中的40名）在96小时前开始分娩活动，而使用泼尼松龙治疗的女性中这一比例为50%（30名女性中的15名）/p<0.02/。在使用阿普罗芬治疗的女性中，31%（40名女性中的14名）通过缩宫素刺激引产，而使用泼尼松龙治疗的女性中这一比例为76%（15名女性中的10名）/p<0.05/。根据克利福德标准，使用皮质类固醇治疗的孕妇中，有高比例的新生儿表现出过期产迹象——23.3%，而使用阿普罗芬治疗的女性中这一比例为9.8%（p<0.01），这表明使用皮质类固醇与新生儿过期产迹象发生率增加之间存在关联。
