Iancu L, Shneur A, Cohen H
Dermatologica. 1979;159(1):55-61. doi: 10.1159/000250562.
The psoriatic epidermis is more active metabolically and its rate of proliferation is faster, showing incomplete differentiation as a result of the imbalance between the low level of cyclic AMP and the high level of cyclic GMP. The low cyclic AMP levels are due to hyperactivity of the phosphodiesterase which hydrolyzes cyclic AMP. Xanthine derivatives are found to be potent phosphodiesterase inhibitors. 15 psoriatic patients were treated with tablets of xanthine derivatives (dyphylline, aminophylline). The obtained results are discussed.
银屑病表皮的代谢更为活跃，增殖速度更快，由于环磷酸腺苷（cAMP）水平低和环磷酸鸟苷（cGMP）水平高之间的失衡，导致分化不完全。cAMP水平低是由于水解cAMP的磷酸二酯酶活性过高。发现黄嘌呤衍生物是有效的磷酸二酯酶抑制剂。15例银屑病患者接受了黄嘌呤衍生物（二羟丙茶碱、氨茶碱）片剂治疗。对所得结果进行了讨论。
