Hasselmark L, Malmgren R, Unge G, Zetterström O
Dept. of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden.
Allergy. 1990 Oct;45(7):523-7. doi: 10.1111/j.1398-9995.1990.tb00528.x.
Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0 +/- 7.1 U/10(11) platelets, which is significantly lower than that of 56.4 +/- 12 U/10(11) platelets in the controls (P less than 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.
