Ecoiffier Tatiana, Sadovnikova Anna, Yuen Don, Chen Lu
Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, CA 94720, USA.
J Ophthalmol. 2012;2012:953187. doi: 10.1155/2012/953187. Epub 2012 Mar 15.
Due to its unique characteristics, the cornea has been widely used for vascular research. However, it has never been studied whether lymphatic vessels in the conjunctiva, its neighboring tissue, are affected by corneal lymphangiogenesis (LG). The purpose of this study was to investigate whether the distribution pattern of conjunctival lymphatic vessels changes during LG using a standardized two-suture placement model. Our data from immunofluorescent microscopic studies demonstrate, for the first time, that conjunctival lymphatic vessels were more distributed in the nasal side under both normal and inflamed conditions. Additionally, under the inflamed condition, conjunctival lymphatic vessels showed a higher density and more branching points, indicating that LG occurs in the conjunctiva in response to corneal inflammation. This study not only provides novel insights into lymphatic events in the ocular surface but also offers new guidelines for developing therapeutic strategies to treat lymphatic diseases at related sites.
由于其独特的特性，角膜已被广泛用于血管研究。然而，其相邻组织结膜中的淋巴管是否受角膜淋巴管生成（LG）影响，此前从未有过研究。本研究的目的是使用标准化的双缝植入模型，调查结膜淋巴管的分布模式在LG过程中是否发生变化。我们免疫荧光显微镜研究的数据首次表明，在正常和炎症条件下，结膜淋巴管在鼻侧分布更多。此外，在炎症条件下，结膜淋巴管显示出更高的密度和更多的分支点，表明结膜中发生LG以应对角膜炎症。本研究不仅为眼表的淋巴事件提供了新的见解，也为制定治疗相关部位淋巴疾病的治疗策略提供了新的指导方针。
