Szyszkowicz Mieczysław, Porada Eugeniusz
Population Studies Division, Health Canada, 269 Laurier Avenue, Room 3-030, Ottawa, ON, Canada K1A 0K9.
ISRN Neurol. 2012;2012:279051. doi: 10.5402/2012/279051. Epub 2012 Mar 15.
Ambient sulphur dioxide (SO(2)) concentrations may affect the number of female emergency department (ED) visits for migraine. ED visits diagnosed as migraine among females in two cities in Canada, Toronto (N = 704) and Ottawa (N = 3, 358), were analyzed. In the study case-crossover design was used. Conditional logistic regression was realized to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) relative to an increase in an interquartile range (IQR, in Toronto IQR = 2.9 ppb, in Ottawa IQR = 3.9 ppb) of sulphur dioxide. In the constructed conditional logistic regression models, temperature and relative humidity were adjusted in the form of natural splines. In Toronto positive and statistically significant associations of sulphur dioxide with migraine ED visits were obtained: all ages, OR = 1.04 (95% CI: 1.00, 1.08); age group [15, 50], OR = 1.05 (95% CI: 1.01, 1.09). In Ottawa positive correlations were observed: all ages, OR = 1.05 (95% CI: 0.97, 1.13); age group [15, 50], OR = 1.06 (95% CI: 0.97, 1.15). The results suggest that female migraine may be affected by ambient sulphur dioxide.
环境二氧化硫（SO₂）浓度可能会影响女性因偏头痛前往急诊科就诊的次数。对加拿大两个城市多伦多（N = 704）和渥太华（N = 3358）的女性中被诊断为偏头痛的急诊科就诊情况进行了分析。本研究采用病例交叉设计。通过条件逻辑回归来估计相对于二氧化硫四分位间距（IQR，多伦多的IQR = 2.9 ppb，渥太华的IQR = 3.9 ppb）增加的优势比（OR）及其95%置信区间（CI）。在构建的条件逻辑回归模型中，以自然样条的形式对温度和相对湿度进行了调整。在多伦多，二氧化硫与偏头痛急诊科就诊之间存在正向且具有统计学意义的关联：所有年龄段，OR = 1.04（95% CI：1.00，1.08）；年龄组[15, 50]，OR = 1.05（95% CI：1.01，1.09）。在渥太华观察到了正相关：所有年龄段，OR = 1.05（95% CI：0.97，1.13）；年龄组[15, 50]，OR = 1.06（95% CI：0.97，1.15）。结果表明，女性偏头痛可能受到环境二氧化硫的影响。
