Szyszkowicz Mieczyslaw
Air Health Effects Division, Health Canada, Ottawa, ON, Canada.
Headache. 2008 Jul;48(7):1076-81. doi: 10.1111/j.1526-4610.2007.01039.x. Epub 2008 Jan 24.
No extensive studies exist on the relation between ambient air pollution and health outcomes such as migraine or headache. From other side, existing publications indicated that air pollutants can trigger migraine or headache.
To examine associations between emergency department (ED) visits for headache and environmental conditions: ambient air pollution concentrations adjusted for weather factors (atmospheric pressure, temperature, and relative humidity).
This is a time-series study of 8012 ED visits for headache (International Classification for Diseases ninth revision: 784) recorded at an Ottawa hospital between 1992 and 2000. The generalized linear mixed models technique is used to model relation between daily counts of ED visits for headache and ambient air pollutants (gases: sulphur dioxide [SO(2)], nitrogen dioxide [NO(2)], carbon monoxide [CO]). The counts of visits for all patients, male and female patients, are analyzed separately.
The percentage increase in daily ED visits for headache was 4.2% (95% CI: 0.2, 6.4) and 4.9% (95% CI: 1.2, 8.8) for 1-day and 2-day lagged exposure to SO(2) for an increase in the interquartile range (IQR, IQR = 3.9 ppb). The positive statistically significant associations were also observed for exposure to NO(2) and CO for all and male ED visits for headache.
Presented findings provide support for the hypothesis that ED visits for headache are related to ambient air pollution.
关于环境空气污染与偏头痛或头痛等健康结果之间的关系，目前尚无广泛研究。另一方面，现有出版物表明空气污染物可引发偏头痛或头痛。
研究因头痛前往急诊科就诊与环境状况之间的关联：根据天气因素（气压、温度和相对湿度）调整后的环境空气污染浓度。
这是一项时间序列研究，对1992年至2000年期间渥太华一家医院记录的8012例因头痛前往急诊科就诊的病例（国际疾病分类第九版：784）进行分析。采用广义线性混合模型技术，对因头痛前往急诊科就诊的每日次数与环境空气污染物（气体：二氧化硫[SO₂]、二氧化氮[NO₂]、一氧化碳[CO]）之间的关系进行建模。对所有患者、男性患者和女性患者的就诊次数分别进行分析。
对于四分位数间距增加（IQR，IQR = 3.9 ppb）的情况，1天和2天滞后暴露于SO₂时，因头痛前往急诊科就诊的每日次数增加百分比分别为4.2%（95%置信区间：0.2，6.4）和4.9%（95%置信区间：1.2，8.8）。对于所有因头痛前往急诊科就诊的患者以及男性患者，暴露于NO₂和CO时也观察到了具有统计学意义的正相关。
本研究结果支持因头痛前往急诊科就诊与环境空气污染有关这一假设。
