皮肤癣菌病患者的即刻超敏反应和血清 IgE 抗体应答。

Immediate hypersensitivity and serum IgE antibody responses in patients with dermatophytosis.

机构信息

Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

出版信息

Asian Pac J Allergy Immunol. 2012 Mar;30(1):40-7.

Abstract

BACKGROUND

The association of dermatophytes with atopic patients and improvement in allergic signs with antifungal treatment suggest a possible link between chronic infection and atopy.

OBJECTIVE

The purpose of this study was to determine skin reactivity and serum IgE antibody responses in patients with chronic and acute dermatophytosis.

METHODS

One hundred and sixty-three patients with chronic dermatophytosis, 35 patients with acute dermatophytosis, 41 atopic patients and 49 healthy subjects were enrolled in this study. Sensitization to Trichophyton mentagrophytes (T. mentagrophytes), Candida albicans and Aspergillus fumigatus antigens has been evaluated in patients by skin prick test (SPT) and by the presence of specific IgE antibody in enzyme-linked immuno-sorbent assay (ELISA).

RESULTS

Positive immediate hypersensitivity (IH) reactions were obtained in 95.1% of the atopic patients with chronic infection for T. mentagrophytes, representing a significant difference from other patient groups (P < 0.05). Specificanti-T. mentagrophytes IgE antibodies were detected in atopic patients with chronic (65.9%) and acute (50%) dermatophytosis, while none of the atopic subjects had positive IgE reactions to T. mentagrophytes.

CONCLUSION

The results showed significant higher positive IH and specific anti-T. mentagrophytes IgE responses in atopic patients with chronic dermatophytosis than the other groups.

摘要

背景

皮肤癣菌与特应性患者的关联以及抗真菌治疗改善过敏体征表明慢性感染与特应性之间可能存在联系。

目的

本研究旨在确定慢性和急性皮肤癣菌病患者的皮肤反应性和血清 IgE 抗体反应。

方法

本研究纳入了 163 例慢性皮肤癣菌病患者、35 例急性皮肤癣菌病患者、41 例特应性患者和 49 名健康受试者。通过皮肤点刺试验（SPT）和酶联免疫吸附试验（ELISA）检测特应性患者对须癣毛癣菌（T. mentagrophytes）、白色念珠菌和烟曲霉抗原的致敏情况。

结果

95.1%的慢性感染特应性患者对 T. mentagrophytes 产生即刻超敏反应（IH），与其他患者群体有显著差异（P < 0.05）。慢性（65.9%）和急性（50%）皮肤癣菌病的特应性患者均检测到特异性抗 T. mentagrophytes IgE 抗体，而特应性受试者均未对 T. mentagrophytes 产生阳性 IgE 反应。