Fertility Clinic/Center for Preimplantation Genetic Diagnosis, Aarhus University Hospital, Aarhus, Denmark.
Acta Obstet Gynecol Scand. 2012 Jul;91(7):765-8. doi: 10.1111/j.1600-0412.2012.01426.x. Epub 2012 May 22.
Preimplantation genetic diagnosis can be used to establish a pregnancy with an embryo that is human leukocyte antigen (HLA)-matched to a sibling having a hematological or immunological disease and needing a life-saving bone marrow transplantation. The ethical aspects of this procedure have been discussed intensively. The procedure applies where no unrelated HLA-matching donor is available or when transplantation from an HLA-matching sibling is considered a better solution. It is only offered in a limited number of centers in Europe as this is a challenging procedure. Where both HLA matching and diagnosis of a dominant disease are necessary, only a small proportion of the embryos can be used, and the procedure is not always technically feasible. The clinical pregnancy rate per cycle started is much lower than following normal in vitro fertilization (IVF) due to a high cycle cancellation rate, but the success rate is only somewhat lower when measured per transfer.
胚胎植入前遗传学诊断可用于建立妊娠，胚胎与患有血液或免疫疾病并需要挽救生命的骨髓移植的兄弟姐妹的人类白细胞抗原 (HLA) 相匹配。该程序的伦理方面已经进行了深入讨论。该程序适用于没有相关 HLA 匹配供体的情况，或者当从 HLA 匹配的兄弟姐妹进行移植被认为是更好的解决方案的情况。由于这是一项具有挑战性的程序，因此仅在欧洲的少数几个中心提供。在需要 HLA 匹配和显性疾病诊断的情况下，只有一小部分胚胎可用，并且该程序并非总是在技术上可行。由于周期取消率高，每个周期开始的临床妊娠率远低于正常体外受精 (IVF)，但每转移的成功率仅略低。
