Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.
Annu Rev Biochem. 2012;81:203-29. doi: 10.1146/annurev-biochem-060310-170328. Epub 2012 Apr 10.
The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code.
泛素化是一种翻译后修饰过程，它几乎控制着细胞中的每一个过程。泛素可以作为单个部分或多聚体链的形式连接到底物蛋白上，其中连续的泛素分子通过特定的异肽键连接。这种修饰方式类似于一种密码，各种泛素修饰采用不同的构象，并在细胞中产生不同的结果。在这里，我们讨论这种泛素密码的结构、组装和功能。
