College of Dentistry & Applied Biomedical Sciences, King Saud University, Riyadh, Saudi Arabia.
J Periodontol. 2013 Mar;84(3):371-8. doi: 10.1902/jop.2012.120146. Epub 2012 Apr 23.
Use of collagen membrane (CM) with xenograft and recombinant human platelet-derived growth factor (rhPDGF) in guided bone regeneration (GBR) is debatable. The aim of this microcomputed tomographic experiment was to assess the efficacy of using PDGF and xenograft (with or without CM) for GBR around immediate implants with dehiscence defects.
Ten beagle dogs underwent atraumatic bilateral second and fourth premolar extractions from both arches. A standardized dehiscence defect (6 × 3 mm) was created on the buccal bone and immediate implants were placed in distal sockets in each site. Animals were randomly divided into three groups: 1) group 1, xenograft with rhPDGF was placed and covered with CM; 2) group 2, xenograft with rhPDGF was placed over the defects; and 3) group 3, four immediate implants were associated with dehiscence (controls). After 16 weeks, animals were sacrificed and jaw segments were assessed for buccal bone thickness (BBT), buccal bone volume (BBV), vertical bone height (VBH), and bone-to-implant contact (BIC) using microcomputed tomography.
BBT was higher in group 2 (1.533 ± 0.89 mm) than group 1 (0.745 ± 0.322 mm) (P <0.001) and group 3 (0.257 ± 0.232 mm) (P <0.05). BBV was higher in group 2 (67.87 ± 19.83 mm(3)) than group 1 (42.47 ± 6.78 mm(3)) (P <0.05) and group 3 (19.12 ± 4.06 mm(3)) (P <0.001). VBH was higher in group 2 (6.36 ± 1.37 mm) than group 3 (0.00 ± 0.00 mm) (P <0.001). VBH was higher in group 1 (3.91 ± 2.68 mm) than group 3 (0.00 ± 0.00 mm) (P <0.05). BIC was higher in group 2 (67.25% ± 13.42%) than group 1 (36.25% ± 12.78%) (P <0.05) and group 3 (30.25% ± 7.27%) (P <0.01).
GBR around immediate implants with dehiscence defects using PDGF and xenograft alone resulted in higher BBT, BBV, VBH, and BIC than when performed in combination with CM.
在引导骨再生（GBR）中使用胶原膜（CM）和异种移植物及重组人血小板衍生生长因子（rhPDGF）存在争议。本微计算机断层扫描实验的目的是评估单独使用 PDGF 和异种移植物（有或没有 CM）治疗即刻种植体周围的骨缺损的效果。
10 只比格犬双侧第二和第四前磨牙均接受了微创拔牙。在颊骨上创建了一个标准的骨开窗缺损（6×3mm），并在每个部位的远侧牙槽窝中放置即刻种植体。动物被随机分为三组：1）组 1，放置 rhPDGF 异种移植物并用 CM 覆盖；2）组 2，将 rhPDGF 异种移植物置于缺损上方；3）组 3，四个即刻种植体与骨开窗（对照）相关联。16 周后，处死动物，使用微计算机断层扫描评估颊骨厚度（BBT）、颊骨体积（BBV）、垂直骨高度（VBH）和骨-种植体接触（BIC）。
组 2 的 BBT（1.533±0.89mm）高于组 1（0.745±0.322mm）（P<0.001）和组 3（0.257±0.232mm）（P<0.05）。组 2 的 BBV（67.87±19.83mm³）高于组 1（42.47±6.78mm³）（P<0.05）和组 3（19.12±4.06mm³）（P<0.001）。组 2 的 VBH（6.36±1.37mm）高于组 3（0.00±0.00mm）（P<0.001）。组 1 的 VBH（3.91±2.68mm）高于组 3（0.00±0.00mm）（P<0.05）。组 2 的 BIC（67.25%±13.42%）高于组 1（36.25%±12.78%）（P<0.05）和组 3（30.25%±7.27%）（P<0.01）。
在即刻种植体周围的骨开窗缺损中单独使用 PDGF 和异种移植物进行 GBR 可获得更高的 BBT、BBV、VBH 和 BIC，而与 CM 联合使用则效果较差。
