Crouch N A, Mitchell R L
Infect Immun. 1979 Jul;25(1):213-9. doi: 10.1128/iai.25.1.213-219.1979.
Previous studies show that Shope fibroma virus facilitates replication of vesicular stomatitis virus (VSV) in some rabbit cells grown in vitro. In the present investigation, the possibility that these two viruses can also interact in vivo was determined. Rabbits inoculated intradermally with both viruses together, or each separately, were examined for the formation of lesions or tumors and for the production of infectious virus. The presence of VSV interfered with tumorigenesis by Shope fibroma virus. In tumors already formed, production of infectious VSV was greater than in normal skin. Hence, each virus affected the other. Sera and tissues of normal rabbits were found to contain a substance which inhibits VSV; this may act to limit replication of VSV in rabbit skin. In addition, cultured rabbit skin cells appeared to adsorb VSV inefficiently. When persistently infected by Shope fibroma virus, however, adsorption of VSV was markedly improved. Our results suggest that in vivo Shope fibroma virus may facilitate adsorption of VSV to reduce the effect of a natural inhibitor and consequently enhance production of infectious virus.
先前的研究表明，肖普纤维瘤病毒可促进水疱性口炎病毒（VSV）在一些体外培养的兔细胞中复制。在本研究中，确定了这两种病毒在体内是否也会相互作用。对同时接种两种病毒或分别接种每种病毒的兔进行皮内接种，检查其病变或肿瘤的形成以及传染性病毒的产生情况。VSV的存在干扰了肖普纤维瘤病毒的致瘤作用。在已形成的肿瘤中，传染性VSV的产生量高于正常皮肤。因此，每种病毒都会对另一种病毒产生影响。发现正常兔的血清和组织中含有一种抑制VSV的物质；这可能起到限制VSV在兔皮肤中复制的作用。此外，培养的兔皮肤细胞似乎对VSV的吸附效率较低。然而，当被肖普纤维瘤病毒持续感染时，VSV的吸附明显改善。我们的结果表明，在体内肖普纤维瘤病毒可能促进VSV的吸附，以降低天然抑制剂的作用，从而提高传染性病毒的产生。
