Whitcomb Emily L, Horgan Santiago, Donohue Michael C, Lukacz Emily S
Southern California Permanente Medical Group, Irvine, CA, USA.
Int Urogynecol J. 2012 Aug;23(8):1111-6. doi: 10.1007/s00192-012-1756-5. Epub 2012 Apr 12.
Given the increased prevalence of obesity and pelvic floor disorders (PFDs), we estimated changes in prevalence, bother, and quality of life (QOL) for PFDs in obese women undergoing bariatric surgery. We hypothesized PFDs would improve after surgical weight loss.
The prevalence, bother, and QOL impact of PFDs were estimated using validated measures. McNemar's and paired t tests were used to compare pre- and postprocedural outcomes. Power calculations deemed that 90 individuals would achieve at least 80 % power to detect a decrease in prevalence of 12 %.
The baseline mean (± standard deviation) age and body mass index (BMI) of the 98 women were 43.3 ± 11.8 years and 39.7 ± 6.2 kg/m.(2) BMI decreased to 34.4 ± 5.8 at 6 months and 34.0 ± 5.6 at 12 months. Whereas the overall prevalence of stress urinary incontinence (SUI) decreased from 22/69 (32 %) at baseline to 10/69 (15 %) at 6 months (p = 0.006) and 14/69 (20 %) at 12 months (p = 0.027), there were no significant decreases in overall prevalence of other PFDs. However, for women with SUI, overactive bladder (OAB), and anal incontinence at baseline, 11/23 (48 %), 8/11 (73 %) and 4/20 (20 %) resolved at 12 months, respectively. Pelvic Floor Impact Questionnaire scores decreased from baseline to 12 months (p < 0.001). Mean visual analog scores for women with SUI, OAB, and anal incontinence decreased at 12 months.
Surgical weight loss resulted in resolution of symptoms in nearly half of women with SUI and three quarters of women with OAB and was associated with significant improvement in QOL.
鉴于肥胖症和盆底功能障碍(PFD)的患病率不断上升,我们估计了接受减肥手术的肥胖女性中PFD的患病率、困扰程度和生活质量(QOL)的变化。我们假设手术减肥后PFD会得到改善。
使用经过验证的测量方法来估计PFD的患病率、困扰程度和对QOL的影响。采用McNemar检验和配对t检验来比较术前和术后的结果。功效计算表明,90名个体将有至少80%的功效检测到患病率下降12%。
98名女性的基线平均(±标准差)年龄和体重指数(BMI)分别为43.3±11.8岁和39.7±6.2kg/m²。BMI在6个月时降至34.4±5.8,在12个月时降至34.0±5.6。虽然压力性尿失禁(SUI)的总体患病率从基线时的22/69(32%)降至6个月时的10/69(15%)(p = 0.006)和12个月时的14/69(20%)(p = 0.027),但其他PFD的总体患病率没有显著下降。然而,对于基线时有SUI、膀胱过度活动症(OAB)和肛门失禁的女性,12个月时分别有11/23(48%)、8/11(73%)和4/20(20%)的症状得到缓解。盆底影响问卷得分从基线到12个月有所下降(p < 0.001)。SUI、OAB和肛门失禁女性的平均视觉模拟评分在12个月时下降。
手术减肥使近一半的SUI女性和四分之三的OAB女性症状得到缓解,并与QOL的显著改善相关。