Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Reprod Sci. 2012 Sep;19(9):962-7. doi: 10.1177/1933719112438970. Epub 2012 Apr 23.
The human µ-opioid receptor (MOR) is the major site of action of endogenous opioids and most of the clinically used opioid analgesics. The single-nucleotide polymorphism (SNP), A118G of the MOR 1 gene (OPRM1), has been associated with altered pain perception. The aim of this study was to investigate whether this polymorphism of OPRM1 is associated with a number of pain-related behaviors during labor. In this observational retrospective population-based study, pregnant women (n = 814) were recruited at gestational week 18. A plasma sample was collected from each participant and an SNP genotyping assay was performed. No differences in sociodemographic variables or labor pain-related outcomes, such as stage of cervical dilation on arrival at the delivery unit or use of any type of second-line analgesia during spontaneous labor, were found between noncarriers and G-allele carriers of OPRM1. We conclude that there is no association between the A118G polymorphism of OPRM1 regarding pain-related behavior during labor.
人类 μ-阿片受体（MOR）是内源性阿片类药物和大多数临床使用的阿片类镇痛药的主要作用部位。MOR1 基因（OPRM1）的单核苷酸多态性（SNP）A118G 与疼痛感知改变有关。本研究旨在探讨 OPRM1 这一 SNP 是否与分娩期间的多种疼痛相关行为有关。在这项观察性回顾性基于人群的研究中，在妊娠第 18 周招募了孕妇（n=814）。从每位参与者采集血浆样本并进行 SNP 基因分型检测。未发现 OPRM1 非携带者和 G 等位基因携带者在社会人口统计学变量或与分娩疼痛相关的结局（如到达分娩单位时的宫颈扩张程度或在自然分娩期间使用任何类型的二线镇痛药物）方面存在差异。我们得出结论，OPRM1 的 A118G 多态性与分娩期间的疼痛相关行为之间没有关联。
