梭果大戟对白化大鼠利尿活性的研究。
Study on the diuretic activity of Euphorbia fusiformis Buch.-Ham. in albino rats.
作者信息
Ashok B K, Bhat Savitha D, Shukla V J, Ravishankar B
机构信息
Research Assistant, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
出版信息
Ayu. 2011 Jul;32(3):385-7. doi: 10.4103/0974-8520.93920.
The present study was undertaken to evaluate diuretic activity of Euphorbia fusiformis root powder in Wistar strain albino rats. Randomly selected animals were divided into three groups of six animals each. The root powder was suspended in distilled water and administered orally at a dose of 90 mg/kg therapeutically equivalent dose (TED) and 180 mg/kg (TED × 02) to overnight fasted rats. The diuretic activity was evaluated by determination of urine volume and urinary electrolyte concentrations. Test drug showed significant increase in urine volume and urinary electrolyte excretion in a dose-dependant manner. Thus, from this study, it can be concluded that roots of E. fusiformis possess diuretic activity.
本研究旨在评估梭形大戟根粉对Wistar品系白化大鼠的利尿活性。随机选取动物，分为三组，每组六只。将根粉悬浮于蒸馏水中，以90mg/kg治疗等效剂量（TED）和180mg/kg（TED×02）的剂量口服给予过夜禁食的大鼠。通过测定尿量和尿电解质浓度来评估利尿活性。受试药物呈剂量依赖性地显著增加尿量和尿电解质排泄。因此，从本研究可以得出结论，梭形大戟的根具有利尿活性。
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