Division of Neonatology, Gulhane Military Medical Academy, Ankara, Turkey.
Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):325-7.
Ibuprofen is used for the closure of ductus arteriosus either intravenously or enterally. Although intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, transient renal failure, oliguria, hyponatremia and thrombocytopenia are reported complications during or after ibuprofen treatment, gastrointestinal bleeding, to our knowledge, has not been reported previously. We herein report a premature newborn, in whom ibuprofen was used intravenously for the closure of ductus arteriosus and gastrointestinal bleeding developed as a complication, and aim to discuss this rare adverse effect. In conclusion, we emphasize the importance of close follow-up of premature newborns during intravenous ibuprofen treatment considering also the other rare systemic side effects reported in the literature.
布洛芬用于静脉内或肠内关闭动脉导管。尽管有报道称在布洛芬治疗期间或之后会出现颅内出血、坏死性小肠结肠炎、支气管肺发育不良、短暂性肾功能衰竭、少尿、低钠血症和血小板减少症等并发症，但据我们所知，尚未有胃肠道出血的报道。我们在此报告一例早产儿，静脉内使用布洛芬关闭动脉导管，并发胃肠道出血，并旨在讨论这种罕见的不良反应。总之，我们强调在静脉内使用布洛芬治疗早产儿时要密切随访，同时也要考虑文献中报道的其他罕见的全身副作用。
