Department of Neurosurgery, University of Split School of Medicine, Soltanska, Split, Croatia.
Spine (Phila Pa 1976). 2012 Oct 15;37(22):1874-82. doi: 10.1097/BRS.0b013e31825a2c2b.
Spine deformity and pain-related behavior after laminectomy with and without spine stabilization were investigated.
We tested hypothesis that spine stabilization after extensive laminectomy can prevent spine deformation and consequent pain-related behavior.
Various ablative procedures requiring laminectomy have been tested for prevention or reversal of pain-related behavior in studies using experimental animals. However, there is no precise description indicating how laminectomy should be performed. Lack of standardized surgical techniques makes it difficult to achieve uniformity of result reporting and to compare results of different research groups meaningfully.
To test our hypothesis, extensive laminectomy with and without spine stabilization was performed in Sprague-Dawley rats. U-shaped surgical wire was used for stabilization of the spine. A validated test of mechanical hyperalgesia was used to test the development of neuropathic pain behavior after surgery. Deformity of the spine was evaluated by calculating deviation from the central axis on radiographs obtained in anteroposterior projection.
Surgical stabilization of the spine after laminectomy prevented development of spinal deformity. Laminectomy without stabilization induced hyperalgesia on the 8th and 15th days after surgery. Group with stabilized spine exhibited significant reduction in pain-related behavior on the 8th and 15th postoperative days compared with the group without stabilization.
Surgical stabilization of the spine after laminectomy prevented development of spinal deformity and pain-related behavior. Our results suggest that spine stabilization procedure should be used in all experimental pain models in which laminectomy is performed.
研究了行广泛椎板切除术后行脊柱稳定与不行脊柱稳定对脊柱畸形和疼痛相关行为的影响。
我们验证了如下假说，即广泛椎板切除术后行脊柱稳定术可防止脊柱畸形和由此引起的疼痛相关行为。
已有多种需要行椎板切除术的消融性操作被用于动物实验，以预防或逆转疼痛相关行为。然而，目前并无确切的描述指出应如何进行椎板切除术。缺乏标准化的手术技术使得难以实现结果报告的一致性，并难以有意义地比较不同研究组的结果。
为了验证我们的假说，在 Sprague-Dawley 大鼠中进行了广泛椎板切除伴或不伴脊柱稳定术。U 形手术用钢丝用于脊柱的稳定。采用经过验证的机械性痛觉过敏检测试验来检测手术后神经病理性疼痛行为的发展。通过计算在前后位片上脊柱偏离中轴线的程度来评估脊柱的畸形。
椎板切除术后行脊柱稳定术可防止脊柱畸形的发展。未行稳定术的椎板切除术在术后第 8 天和第 15 天引起痛觉过敏。与未行稳定术的组相比，行稳定术的组在术后第 8 天和第 15 天的疼痛相关行为显著减少。
椎板切除术后行脊柱稳定术可防止脊柱畸形和疼痛相关行为的发生。我们的研究结果表明，在所有进行椎板切除术的实验性疼痛模型中，均应使用脊柱稳定术。
