Simsek Yavuz, Celik Onder, Yilmaz Ercan, Karaer Abdullah, Dogan Cagdas, Aydin Suleyman, Ozer Ali
Department of Obstetrics and Gynecology, Inonu University Faculty of Medicine, Malatya, Turkey.
J Matern Fetal Neonatal Med. 2012 Sep;25(9):1705-8. doi: 10.3109/14767058.2011.660221. Epub 2012 Apr 25.
The purpose of this study was to investigate the relationship between the serum apelin, salusin-alpha and salusin-beta levels and preeclampsia.
Twenty-one healthy pregnant women (control group) and 48 patients with preeclampsia (study group) were included in the study between August 2010 and February 2011. Serum apelin, salusin-alpha and salusin-beta levels of the groups were compared.
The patients in the study group were divided into two categories: mild preeclampsia and severe preeclampsia. The mild preeclampsia group consisted of 31 patients, and the severe preeclampsia group consisted of 17 patients. Serum salusin-alpha and salusin-beta levels of the control and study groups were not significantly different (p > 0.05). Apelin levels were statistically significantly higher in the study group. No statistically significant difference was detected between the mild and severe preeclampsia groups in terms of the mean serum apelin levels.
The serum levels of apelin were higher in the pregnant women with preeclampsia; however, there was no positive relationship between serum salusin-alpha and salusin-beta levels and the disease. Larger prospective studies are needed to validate our findings.
本研究旨在探讨血清阿片肽、Salusin-α和Salusin-β水平与子痫前期之间的关系。
2010年8月至2011年2月期间，本研究纳入了21名健康孕妇（对照组）和48例子痫前期患者（研究组）。比较两组的血清阿片肽、Salusin-α和Salusin-β水平。
研究组患者分为两类：轻度子痫前期和重度子痫前期。轻度子痫前期组有31例患者，重度子痫前期组有17例患者。对照组和研究组的血清Salusin-α和Salusin-β水平无显著差异（p>0.05）。研究组的阿片肽水平在统计学上显著更高。轻度和重度子痫前期组之间的平均血清阿片肽水平未检测到统计学上的显著差异。
子痫前期孕妇的血清阿片肽水平较高；然而，血清Salusin-α和Salusin-β水平与该疾病之间没有正相关关系。需要更大规模的前瞻性研究来验证我们的发现。
