Argent N B, Baylis P H, Wilkinson R
Department of Medicine, University of Newcastle upon Tyne, UK.
Clin Chim Acta. 1990 Oct 15;190(3):185-8. doi: 10.1016/0009-8981(90)90172-o.
Patients with end stage renal failure have been shown to have higher basal concentrations of plasma arginine vasopressin than subjects with normal renal function. Immunoreactive vasopressin was detected in plasma from patients with severe chronic renal failure and a healthy subject at an elution volume identical to that previously determined with synthetic vasopressin. Assay of all fractions yielded identical chromatograms in the renal failure and healthy control groups. We conclude that the plasma immunoreactive vasopressin in end stage renal failure plasma coelutes with synthetic vasopressin and that the elevated concentrations found in these patients are not due to non-specific depression of binding in the vasopressin radioimmunoassay by circulating substances in renal failure.
终末期肾衰竭患者血浆精氨酸加压素的基础浓度高于肾功能正常的受试者。在严重慢性肾衰竭患者和一名健康受试者的血浆中检测到免疫反应性加压素，其洗脱体积与先前用合成加压素测定的洗脱体积相同。对所有组分的检测在肾衰竭组和健康对照组中产生了相同的色谱图。我们得出结论，终末期肾衰竭血浆中的血浆免疫反应性加压素与合成加压素共洗脱，并且这些患者中发现的浓度升高并非由于肾衰竭中循环物质对加压素放射免疫测定中结合的非特异性抑制所致。
