Hospital Universitário, Universidade Federal do Maranhão, São Luis, MA, Brasil.
Arq Bras Cardiol. 2012 Jun;98(6):505-13. doi: 10.1590/s0066-782x2012005000040. Epub 2012 Apr 26.
Cardiac disorders are very common in individuals with chronic kidney disease and are associated with morbimortality.
To evaluate cardiac alterations after kidney transplantation.
We prospectively evaluated 40 patients with chronic kidney disease, immediately before and one month, three months and six months after kidney transplantation, using tissue Doppler echocardiographic study. The left ventricular mass, systolic and diastolic function parameters were analyzed.
The mean age was 31.6 years and 40% of patients were female. We observed a reduction in left ventricular diastolic diameter (52.23 to 49.95 mm, p = 0.021) and LV mass index (131.48 to 113.039 g/m2, p = 0.002) after kidney transplantation. The mean E/e' decreased in the third and sixth months after kidney transplantation, when compared to basal values (8.13 and 7.85 vs. 9.79, p <0.05). The ejection fraction increased from the first month after kidney transplantation compared to basal assessment (69.72% vs. 65.68%, p <0.05). The prevalence of diastolic dysfunction decreased 43% during the evaluated period. The basal ejection fraction and mean E/e' were associated with reduced LV mass index after kidney transplantation. The LV mass index at baseline, female sex and decrease in serum phosphorus were associated with a reduction in the mean E/e ' ratio after kidney transplantation.
Kidney transplantation resulted in significant alterations in Doppler echocardiographic parameters of LV mass, systolic and diastolic function in patients with chronic kidney disease.
心脏疾病在慢性肾脏病患者中非常常见，并与发病率和死亡率相关。
评估肾移植后心脏的改变。
我们前瞻性评估了 40 例慢性肾脏病患者，在肾移植前、移植后 1 个月、3 个月和 6 个月，使用组织多普勒超声心动图研究。分析左心室质量、收缩和舒张功能参数。
患者的平均年龄为 31.6 岁，40%为女性。我们观察到肾移植后左心室舒张直径（从 52.23 毫米降至 49.95 毫米，p = 0.021）和左心室质量指数（从 131.48 克/平方米降至 113.039 克/平方米，p = 0.002）降低。与基础值相比，肾移植后第 3 个月和第 6 个月的平均 E/e'降低（8.13 和 7.85 比 9.79，p <0.05）。与基础评估相比，肾移植后第 1 个月的射血分数增加（69.72%比 65.68%，p <0.05）。在评估期间，舒张功能障碍的患病率降低了 43%。基础射血分数和平均 E/e'与肾移植后左心室质量指数降低相关。基线时的左心室质量指数、女性和血清磷降低与肾移植后平均 E/e '比值降低相关。
肾移植导致慢性肾脏病患者左心室质量、收缩和舒张功能的多普勒超声心动图参数发生显著改变。
