Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory for Molecular Biology, Institute of Biochemistry and Cell biology, Shanghai, China.
Genes Immun. 2012 Sep;13(6):445-51. doi: 10.1038/gene.2012.13. Epub 2012 Apr 26.
The mBin1b is a beta-defensin gene identified in the mouse epididymis. In the current report, its expression pattern and antibacterial activities were characterized, and a transgenic (TG) mouse model was developed in which mBin1b was exclusively overexpressed by up to 50-fold over normal levels in the caput epididymis. The experimental animals are healthy with normal reproductive activity, but are more resistant to epididymal infection from Escherichia coli than normal animals. The expression of IL1α and IL1β in the epididymis was decreased in the TG mice, which suggests that mBin1b has a role in the regulation of inflammatory response in the epididymis.
mBin1b 是在小鼠附睾中鉴定出的一种β-防御素基因。在本报告中，对其表达模式和抗菌活性进行了表征，并建立了一个转基因 (TG) 小鼠模型，其中 mBin1b 在附睾头部的表达水平比正常水平高出 50 倍。实验动物健康，生殖活动正常，但对大肠杆菌引起的附睾感染的抵抗力比正常动物强。TG 小鼠附睾中 IL1α 和 IL1β 的表达降低，这表明 mBin1b 在附睾炎症反应的调节中起作用。
