胰岛素、N6-（苯异丙基）腺苷和2'，5'-二脱氧腺苷对离体大鼠脂肪细胞中环磷酸腺苷代谢和脂肪分解的调节
Regulation of cyclic AMP metabolism and lipolysis in isolated rat fat cells by insulin, N6-(phenylisopropyl) adenosine and 2',5'-dideoxyadenosine.
作者信息
Fain J N, Li S Y, Moreno F J
出版信息
J Cyclic Nucleotide Res. 1979;5(3):189-96.
The increases in cyclic AMP accumulation and lipolysis by rat fat cells incubated in the presence of catecholamines were abolished by N6-(phenylisopropyl) adenosine. The same inhibition of cyclic AMP accumulation was seen in the presence of 2',5'-dideoxyadenosine but lipolysis was unaffected. In contrast, insulin inhibited lipolysis without affecting cyclic AMP accumulation by norepinephrine plus adenosine deaminase. These results suggest that there are either multiple pools of cyclic AMP or that ther exists some other mechanism which is involved in the regulation of lipolysis by hormones.
在儿茶酚胺存在的情况下孵育的大鼠脂肪细胞中，环磷酸腺苷（cAMP）积累和脂肪分解的增加被N6-（苯异丙基）腺苷消除。在2'，5'-二脱氧腺苷存在的情况下也观察到了对cAMP积累的相同抑制作用，但脂肪分解未受影响。相比之下，胰岛素抑制脂肪分解，而不影响去甲肾上腺素加腺苷脱氨酶引起的cAMP积累。这些结果表明，要么存在多个cAMP池，要么存在其他一些参与激素对脂肪分解调节的机制。
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