激素类药物的体外和体内遗传毒性评估。I. 氢化可的松。

In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.

作者信息

Bali D, Singh J R, Singh H, Sandhu D

机构信息

Department of Human Biology and Human Genetics, Guru Nanak Dev University, Amritsar, India.

出版信息

Environ Mol Mutagen. 1990;16(4):250-4. doi: 10.1002/em.2850160406.

DOI:10.1002/em.2850160406

PMID:2253604

Abstract

Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/Salmonella assay both with and without S9 did not show an increase in the His+ revertants.

摘要

使用一系列体外和体内测试系统，对一种广泛使用的糖皮质激素氢化可的松进行了遗传毒性评估。人类淋巴细胞培养和小鼠骨髓研究（微核和姐妹染色单体交换分析）表明该药物是一种非常强效的断裂剂。然而，无论有无S9的艾姆斯/沙门氏菌试验均未显示组氨酸营养缺陷型回复突变体增加。