激素类药物的体外和体内遗传毒性评估。II. 地塞米松。
In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
作者信息
Singh H, Singh J R, Dhillon V S, Bali D, Paul H
机构信息
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
出版信息
Mutat Res. 1994 Jul 1;308(1):89-97. doi: 10.1016/0027-5107(94)90201-1.
Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
使用体外和体内试验对一种广泛使用的糖皮质激素药物地塞米松进行了遗传毒性评估。对人类淋巴细胞中的染色体畸变、姐妹染色单体交换（SCE）以及小鼠骨髓中的微核和SCE进行分析，结果表明该药物能够攻击遗传物质。然而，无论有无S9混合物，艾姆斯/沙门氏菌试验均未显示组氨酸营养缺陷型回复突变体有任何增加。
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