Kabata Yoshiaki, Takahashi Genichiro, Tsuneoka Hiroshi
Department of Ophthalmology, Jikei University School of Medicine, Katsushika Medical Center, Katsushika, Tokyo, Japan.
Clin Ophthalmol. 2012;6:521-3. doi: 10.2147/OPTH.S31130. Epub 2012 Mar 27.
A case of cytomegalovirus (CMV) retinitis in a patient with Wegener's granulomatosis treated with oral valganciclovir as maintenance therapy is reported. A 68-year-old male patient with anti-proteinase-3 ANCA-positive Wegener's granulomatosis who was receiving immunosuppressive therapy with methylprednisolone, cyclophosphamide, and azathioprine developed CMV retinitis. The patient received intravenous ganciclovir as induction therapy and oral valganciclovir as maintenance therapy. The patient responded to treatment and showed no recurrence for 8 months. There were no serious adverse effects associated with oral valganciclovir. Oral valganciclovir is convenient and effective for the management of CMV retinitis in the patient with Wegener's granulomatosis.
报告了1例韦格纳肉芽肿患者接受口服缬更昔洛韦作为维持治疗的巨细胞病毒（CMV）视网膜炎病例。1名68岁男性患者，抗蛋白酶3抗中性粒细胞胞浆抗体（ANCA）阳性的韦格纳肉芽肿，正在接受甲泼尼龙、环磷酰胺和硫唑嘌呤免疫抑制治疗，发生了CMV视网膜炎。该患者接受静脉注射更昔洛韦作为诱导治疗，口服缬更昔洛韦作为维持治疗。患者对治疗有反应，8个月未复发。口服缬更昔洛韦未出现严重不良反应。口服缬更昔洛韦对韦格纳肉芽肿患者CMV视网膜炎的治疗方便且有效。
