Saberi Parya, Dong Betty J, Johnson Mallory O, Greenblatt Ruth M, Cocohoba Jennifer M
Department of Medicine, University of California, San Francisco, CA, USA.
Patient Prefer Adherence. 2012;6:297-322. doi: 10.2147/PPA.S30244. Epub 2012 Apr 5.
Due to the rapid proliferation of human immunodeficiency virus (HIV) treatment options, there is a need for health care providers with knowledge of antiretroviral therapy intricacies. In a HIV multidisciplinary care team, the HIV pharmacist is well-equipped to provide this expertise. We conducted a systematic review to assess the impact of HIV pharmacists on HIV clinical outcomes.
We searched six electronic databases from January 1, 1980 to June 1, 2011 and included all quantitative studies that examined pharmacist's roles in the clinical care of HIV-positive adults. Primary outcomes were antiretroviral adherence, viral load, and CD(4) (+) cell count and secondary outcomes included health care utilization parameters, antiretroviral modifications, and other descriptive variables.
Thirty-two publications were included. Despite methodological limitation, the involvement of HIV pharmacists was associated with statistically significant adherence improvements and positive impact on viral suppression in the majority of studies.
This systematic review provides evidence of the beneficial impact of HIV pharmacists on HIV treatment outcomes and offers suggestions for future research.
由于人类免疫缺陷病毒（HIV）治疗方案迅速增加，需要医疗服务提供者了解抗逆转录病毒疗法的复杂性。在HIV多学科护理团队中，HIV药剂师具备提供此类专业知识的能力。我们进行了一项系统评价，以评估HIV药剂师对HIV临床结局的影响。
我们检索了1980年1月1日至2011年6月1日期间的六个电子数据库，纳入了所有研究药剂师在HIV阳性成年人临床护理中作用的定量研究。主要结局为抗逆转录病毒治疗的依从性、病毒载量和CD4（+）细胞计数，次要结局包括医疗保健利用参数、抗逆转录病毒治疗方案的调整以及其他描述性变量。
纳入32篇出版物。尽管存在方法学局限性，但在大多数研究中，HIV药剂师的参与与依从性的显著改善以及对病毒抑制的积极影响相关。
本系统评价提供了证据，证明HIV药剂师对HIV治疗结局有有益影响，并为未来研究提供了建议。
