Di Blasi A, Fuligni A, Geti V, Battini M L, Fabbri P
Clinica Dermosifilopatica, Università di Firenze.
G Ital Dermatol Venereol. 1990 May;125(5):169-72.
The paper reports the results of a preliminary study using indirect immunofluorescent methods on serum samples from 20 patients affected by dermatitis herpetiformis in various phases of development and from 7 patients affected by celiac disease in order to document the presence of anti-endomysium IgA antibodies. Serum samples from 10 patients affected by bullous pemphigoid, 1 patients with linear IgA dermatitis and 10 patients with other bullous dermatosis were included as controls. Whereas the presence of these antibodies in varying titres, ranging from 1:10 to 1:80, was confirmed in all case of dermatitis herpetiformis, no antibody activity was observed in control patients. On the basis of these findings and of other published data, it is possible to conclude that these antibodies are directly correlated to intestinal damage, but there is no relationship with the clinical characteristics of skin symptoms or with junctional immunopathological evidence.
该论文报告了一项初步研究的结果，该研究采用间接免疫荧光法对20例处于不同发展阶段的疱疹样皮炎患者以及7例乳糜泻患者的血清样本进行检测，以证实抗肌内膜IgA抗体的存在。选取了10例大疱性类天疱疮患者、1例线状IgA皮炎患者和10例其他大疱性皮肤病患者的血清样本作为对照。结果显示，所有疱疹样皮炎患者均证实存在滴度从1:10至1:80不等的这些抗体，而对照患者未观察到抗体活性。基于这些发现以及其他已发表的数据，可以得出结论，这些抗体与肠道损伤直接相关，但与皮肤症状的临床特征或交界性免疫病理证据无关。
