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[儿童良性慢性大疱性皮肤病。与疱疹样皮炎和大疱性类天疱疮的鉴别诊断]

[Childhood benign chronic bullous dermatosis. Differential diagnosis with dermatitis herpetiformis and bullous pemphigoid].

作者信息

Casanova J M, Vives P, Hernanz J M, Cimadevilla J C, González C M

出版信息

An Esp Pediatr. 1985 Jan;22(1):37-42.

PMID:3885812
Abstract

We review the literature on benign chronic bullous dermatosis of childhood and the criterions for its diagnosis and differentiation from dermatitis herpetiformis and bullous pemphigoid. The diagnosis among these conditions should be based on immunofluorescence data. BCBDC shows linear IgA on the basal membrane zone. Its course is benign and there is not enteropathy. In dermatitis herpetiformis we find granular IgA and complement in the tips of dermal papillae. It is a chronic illness and the patients have a gluten-sensitive enteropathy. The bullous pemphigoid is a severe condition which needs corticosteroids for its control. Direct immunofluorescent studies reveal IgG and complement in a linear pattern in the membrane basal zone. It is associated with circulating antibasement membrane zone IgG.

摘要

我们回顾了关于儿童良性慢性大疱性皮肤病的文献,以及其诊断标准,及其与疱疹样皮炎和大疱性类天疱疮的鉴别。这些病症之间的诊断应基于免疫荧光数据。儿童良性慢性大疱性皮肤病在基底膜区显示线性IgA。其病程是良性的,且不存在肠病。在疱疹样皮炎中,我们在真皮乳头尖端发现颗粒状IgA和补体。这是一种慢性病,患者有麸质敏感性肠病。大疱性类天疱疮是一种严重病症,需要使用皮质类固醇进行控制。直接免疫荧光研究显示在膜基底区有呈线性模式的IgG和补体。它与循环抗基底膜区IgG相关。

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