Bazrgar Masood, Karimi Mehran
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Genet Test Mol Biomarkers. 2012 Aug;16(8):920-3. doi: 10.1089/gtmb.2011.0379. Epub 2012 Apr 27.
Hyperuricemia, dyslipidemia, and apolipoprotein E (apoE) polymorphism are risk factors for cardiovascular diseases (CVDs). This study sought to determine the association of apoE gene polymorphism with hyperuricemia and dyslipidemia in young healthy people. Association of serum uric acid (SUA) and serum lipids with apoE was studied by analysis of variance in 198 healthy southern Iranian candidates. Subjects with an E2/E3 genotype had a lower cholesterol level in comparison with E3/E3 individuals. In addition, male E3/E4 subjects had a lower SUA level in comparison with other men. Lower cholesterol levels in E2 carriers mean a lower risk for CVDs, while SUA, as another risk factor for CVDs, in male E4 carriers was low. Regarding the higher risk for CVDs in men and the known role of SUA and apoE polymorphism in CVDs, it is not simple to guess the net effect of each one of these risk factors. This is the first report to study the association between SUA level and apoE in healthy men.
高尿酸血症、血脂异常和载脂蛋白E（apoE）基因多态性是心血管疾病（CVDs）的危险因素。本研究旨在确定年轻健康人群中apoE基因多态性与高尿酸血症和血脂异常之间的关联。通过对198名伊朗南部健康受试者进行方差分析，研究血清尿酸（SUA）和血脂与apoE的相关性。与E3/E3基因型个体相比，E2/E3基因型受试者的胆固醇水平较低。此外，男性E3/E4受试者的SUA水平低于其他男性。E2携带者胆固醇水平较低意味着患心血管疾病的风险较低，而作为心血管疾病另一个危险因素的SUA，在男性EIV携带者中水平较低。鉴于男性患心血管疾病的风险较高以及SUA和apoE基因多态性在心血管疾病中的已知作用，很难推测这些危险因素各自的净效应。这是首份研究健康男性中SUA水平与apoE之间关联的报告。
