体内已丧失毒力基因的产肠毒素大肠杆菌突变体的遗传特征及毒力
Genetic characterization and virulence of enterotoxigenic Escherichia coli mutants which have lost virulence genes in vivo.
作者信息
Casey T A, Moon H W
机构信息
National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010.
出版信息
Infect Immun. 1990 Dec;58(12):4156-8. doi: 10.1128/iai.58.12.4156-4158.1990.
Abstract
Loss of K99 and STaP genes from enterotoxigenic Escherichia coli 431 during infection occurred by either plasmid curing or plasmid deletion. These mutants expressed the F41 adhesion and colonized neonatal pigs, but only those mutants that retained STaP caused diarrhea with significant weight loss.
摘要
在感染过程中，产肠毒素大肠杆菌431的K99和STaP基因通过质粒消除或质粒缺失而丢失。这些突变体表达F41黏附素并定殖于新生仔猪，但只有那些保留STaP的突变体才会导致腹泻并伴有显著体重减轻。
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