Elsinga P H, Daemen B J, Ishiwata K, Vaalburg W
Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands.
Int J Rad Appl Instrum B. 1990;17(6):597-600. doi: 10.1016/0883-2897(90)90135-n.
The aim of this study is to investigate the possibility of measuring ornithine decarboxylase (ODC) activity in tissues such as prostate and tumor, by PET. The ODC activity in vitro and the distribution of L-[1-14C]- and L-[5-14C]ornithine were studied in prostate, tumor, liver and kidney. For the animal models, rats bearing Walker 256 carcinosarcoma, were used. Our results indicate that the ODC activity in prostate is correlated with the difference in uptake between L-[1-14C]- and L-[5-14C]ornithine. Measurement of ODC activity in tumor by PET demands a tumor with an ODC activity comparable to that of prostate. Such a tumor will show a sufficient difference in uptake, which can be detected by PET.
本研究的目的是探讨通过正电子发射断层扫描（PET）测量前列腺和肿瘤等组织中鸟氨酸脱羧酶（ODC）活性的可能性。研究了前列腺、肿瘤、肝脏和肾脏中ODC的体外活性以及L-[1-¹⁴C]-和L-[5-¹⁴C]鸟氨酸的分布。对于动物模型，使用了携带Walker 256癌肉瘤的大鼠。我们的结果表明，前列腺中的ODC活性与L-[1-¹⁴C]-和L-[5-¹⁴C]鸟氨酸摄取差异相关。通过PET测量肿瘤中的ODC活性需要肿瘤的ODC活性与前列腺相当。这样的肿瘤将显示出足够的摄取差异，可通过PET检测到。
