Bolster J M, Vaalburg W, van Dijk T H, Zijlstra J B, Paans A M, Wynberg H, Woldring M G
Int J Appl Radiat Isot. 1985 Apr;36(4):263-7. doi: 10.1016/0020-708x(85)90082-1.
DL-[1-11C]ornithine and lysine have been synthesized by carboxylation of the corresponding alpha-lithioisocyanide with a radiochemical yield of up to 14% without correction for decay. The total preparation time is 50 min. Accumulation of both DL-[1-11C]ornithine and lysine in Walker 256 carcinosarcoma is observed, with a tumor/non-tumor ratio of 4.9 and 4.5 respectively, at 45 min after intravenous injection.
DL-[1-¹¹C]鸟氨酸和赖氨酸是通过相应的α-锂异氰化物的羧化反应合成的，未校正衰变时放射化学产率高达14%。总制备时间为50分钟。静脉注射后45分钟时，观察到DL-[1-¹¹C]鸟氨酸和赖氨酸在Walker 256癌肉瘤中均有蓄积，肿瘤/非肿瘤比值分别为4.9和4.5。
